|By Business Wire||
|July 28, 2014 07:00 AM EDT||
Emulate, Inc. today announced the company’s launch with a $12 million Series A financing to commercialize a first-in-kind, automated ‘Organs-on-Chips’ platform that mimics human physiology and diseases, while permitting real-time elucidation of molecular mechanisms of action and toxicity. Emulate’s proprietary Organs-on-Chips platform achieves a new industry standard by predicting human responses to medicines, chemicals, and toxins more rapidly and with greater fidelity than animal models. The company’s mission is to commercialize its Organs-on-Chips bioemulation products, automated platform and software to enhance innovation and accelerate the development of pharmaceutical, chemical, cosmetic, and personalized medicine products.
The Emulate, Inc. Lung-on-Chip in the photo is lined with human lung and blood vessel cells to create a new living technology platform to emulate human biology (Photo: Business Wire)
“Emulate’s Organs-on-Chips platform provides, for the first time, a window into the inner-workings of human organs without having to invade a living body,” said James Coon, Chief Executive Officer of Emulate. “Our unique automated Organs-on-Chips approach to human bioemulation opens up entirely new possibilities to develop products with enhanced properties, improved efficacy and safety, and personalization to patients and consumers. The company will focus on key strengths of integrating design, biology and engineering to create revolutionary products. We are launching Emulate to be a leader in advancing innovative product design across multiple industries including drug development, healthcare, agriculture and consumer health.”
Emulate will use the proceeds from the financing to advance the first commercial applications of its automated Organs-on-Chips platform through co-innovation with corporate and clinical clients, and through internal development programs. The company’s initial focus will be use of Organs-on-Chips to provide more rapid and accurate evaluation of human responses to drugs and cosmetics, and to create new clinical guidance tools for personalized therapies. The Series A financing was led by the venture capital firm NanoDimension, alongside of investment by Cedars-Sinai Medical Center and private investor Hansjörg Wyss.
“Emulate’s platform has significant potential to advance human health today, not only to better design and evaluate new breakthrough medicines, but also to drive more personalized diagnosis and treatment approaches,” said Shlomo Melmed, M.D., Senior Vice President for Academic Affairs and Dean of the Medical Faculty at Cedars-Sinai. “Our vision is we can one day put each patient’s cells on chips that mimic the function of organs, and this will open up new ways for us to design truly personalized treatment with stem cells, based on each patient’s unique genetic profile on their own individualized Organs-on-Chips.”
Leading Foundational Science and Team
The company’s founding team carried out their ground-breaking foundational research, engineering and technology translation at the Wyss Institute for Biologically Inspired Engineering at Harvard University, which has made automated human Organs-on-Chips a reality. The company’s scientific founder and a pioneer in the field of organs-on-chips, Donald Ingber, M.D., Ph.D., Founding Director of the Wyss Institute and faculty member at Harvard Medical School, Harvard School of Engineering and Applied Sciences, and Boston Children’s Hospital will chair Emulate’s Scientific Advisory board. Lead Senior Staff Scientist at the Wyss Institute, Geraldine A. Hamilton, Ph.D., will join as President and Chief Scientific Officer of Emulate. James Coon, Entrepreneur-in-Residence at the Wyss Institute, has been appointed Emulate’s Chief Executive Officer. Hamilton and Coon collectively have over 30 years of experience in biotechnology startups and the pharmaceutical industry.
Emulate has a worldwide license to a robust and broad intellectual property portfolio for its bioemulation Organs-on-Chips platform from Harvard University, and is uniquely positioned to advance the technology into successful commercial applications, supported by multiple years of vigorous research and development by its experienced team of scientists and engineers.
“This advanced technology is the beginning of a revolution in the way we study human biology and disease, as Emulate sets a new standard for products to be aligned with a complete picture of human biology,” said Geraldine A. Hamilton, Ph.D. “Emulate’s Organs-on-Chips allow living human cells to interact with other cell types within the authentic physical context of living tissues and organs as they would normally in the human body. This ability to bioemulate the human organ microenvironment through microengineering – combined with automated instrumentation that permits molecular scale analysis in real-time – allows us to replicate, analyze and predict human responses in a truly unique and powerful way.”
Organs-on-Chips for Human Bioemulation
Emulate’s technology represent a unique human bioemulation platform that permits analysis of molecular functions within human cells living in an engineered microenvironment that accurately recapitulates human organ biology. Human Organs-on-Chips are miniaturized devices created with microchip manufacturing that contain tiny hollow channels lined by living human cells and tissues cultured under continuous fluid flow and mechanical forcing regimens, such as cyclic breathing and peristalsis, which effectively recapitulate organ-level physiology and disease responses. In Emulate’s automated platform, different Organs-on-Chips, such as lung, liver, intestine, kidney, skin, eye, and blood-brain-barrier, can be linked together by flowing liquid containing living human immune cells that simulates blood to form a “Human-Body-on-Chips” to more closely replicate whole body-level responses.
Emulate, Inc. is a private company focused on commercializing Organs-on-Chips as an automated human bioemulation platform that achieves a new standard for mimicking true human physiology so that responses to medicines, chemicals and diseases can be accurately predicted. Through co-innovation with collaborators and internal programs, Emulate is advancing product innovation, design and safety across a range of applications in drug development, personalized medicine, agriculture and chemical-based consumer products. For more information, visit www.emulatebio.com.
NanoDimension is a U.S. and Europe based venture capital firm specializing in nanotechnology. Founded in 2002, NanoDimension invests in early-stage companies that are developing break-through technologies at the nano-scale to disrupt markets and to solve critical global problems. For more information, visit www.nanodimension.com.
Niagara Networks exhibited at the 19th International Cloud Expo, which took place at the Santa Clara Convention Center in Santa Clara, CA, in November 2016. Niagara Networks offers the highest port-density systems, and the most complete Next-Generation Network Visibility systems including Network Packet Brokers, Bypass Switches, and Network TAPs.
Feb. 24, 2017 12:45 AM EST Reads: 952
WebRTC services have already permeated corporate communications in the form of videoconferencing solutions. However, WebRTC has the potential of going beyond and catalyzing a new class of services providing more than calls with capabilities such as mass-scale real-time media broadcasting, enriched and augmented video, person-to-machine and machine-to-machine communications. In his session at @ThingsExpo, Luis Lopez, CEO of Kurento, introduced the technologies required for implementing these idea...
Feb. 23, 2017 11:30 PM EST Reads: 6,280
Why do your mobile transformations need to happen today? Mobile is the strategy that enterprise transformation centers on to drive customer engagement. In his general session at @ThingsExpo, Roger Woods, Director, Mobile Product & Strategy – Adobe Marketing Cloud, covered key IoT and mobile trends that are forcing mobile transformation, key components of a solid mobile strategy and explored how brands are effectively driving mobile change throughout the enterprise.
Feb. 23, 2017 11:00 PM EST Reads: 7,003
Apache Hadoop is emerging as a distributed platform for handling large and fast incoming streams of data. Predictive maintenance, supply chain optimization, and Internet-of-Things analysis are examples where Hadoop provides the scalable storage, processing, and analytics platform to gain meaningful insights from granular data that is typically only valuable from a large-scale, aggregate view. One architecture useful for capturing and analyzing streaming data is the Lambda Architecture, represent...
Feb. 23, 2017 10:00 PM EST Reads: 4,589
SYS-CON Events announced today that delaPlex will exhibit at SYS-CON's @CloudExpo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. delaPlex pioneered Software Development as a Service (SDaaS), which provides scalable resources to build, test, and deploy software. It’s a fast and more reliable way to develop a new product or expand your in-house team.
Feb. 23, 2017 09:15 PM EST Reads: 1,506
The explosion of new web/cloud/IoT-based applications and the data they generate are transforming our world right before our eyes. In this rush to adopt these new technologies, organizations are often ignoring fundamental questions concerning who owns the data and failing to ask for permission to conduct invasive surveillance of their customers. Organizations that are not transparent about how their systems gather data telemetry without offering shared data ownership risk product rejection, regu...
Feb. 23, 2017 08:45 PM EST Reads: 1,289
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo 2016 in New York. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place June 6-8, 2017, at the Javits Center in New York City, New York, is co-located with 20th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry p...
Feb. 23, 2017 08:30 PM EST Reads: 1,445
Extreme Computing is the ability to leverage highly performant infrastructure and software to accelerate Big Data, machine learning, HPC, and Enterprise applications. High IOPS Storage, low-latency networks, in-memory databases, GPUs and other parallel accelerators are being used to achieve faster results and help businesses make better decisions. In his session at 18th Cloud Expo, Michael O'Neill, Strategic Business Development at NVIDIA, focused on some of the unique ways extreme computing is...
Feb. 23, 2017 08:15 PM EST Reads: 8,020
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, demonstrated how to move beyond today's coding paradigm and sh...
Feb. 23, 2017 07:45 PM EST Reads: 3,372
FinTech is the sum of financial and technology, and it’s one of the fastest growing tech industries. Total global investments in FinTech almost reached $50 billion last year, but there is still a great deal of confusion over what it is and what it means – especially as it applies to retirement. Building financial startups is not simple, but with the right team, technology and an innovative approach it can be an extremely interesting domain to disrupt. FinTech heralds a financial revolution that...
Feb. 23, 2017 07:30 PM EST Reads: 1,738
SYS-CON Events announced today that IoT Now has been named “Media Sponsor” of SYS-CON's 20th International Cloud Expo, which will take place on June 6–8, 2017, at the Javits Center in New York City, NY. IoT Now explores the evolving opportunities and challenges facing CSPs, and it passes on some lessons learned from those who have taken the first steps in next-gen IoT services.
Feb. 23, 2017 06:45 PM EST Reads: 1,449
As organizations realize the scope of the Internet of Things, gaining key insights from Big Data, through the use of advanced analytics, becomes crucial. However, IoT also creates the need for petabyte scale storage of data from millions of devices. A new type of Storage is required which seamlessly integrates robust data analytics with massive scale. These storage systems will act as “smart systems” provide in-place analytics that speed discovery and enable businesses to quickly derive meaningf...
Feb. 23, 2017 06:30 PM EST Reads: 6,288
SYS-CON Events announced today that WineSOFT will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Based in Seoul and Irvine, WineSOFT is an innovative software house focusing on internet infrastructure solutions. The venture started as a bootstrap start-up in 2010 by focusing on making the internet faster and more powerful. WineSOFT’s knowledge is based on the expertise of TCP/IP, VPN, SSL, peer-to-peer, mob...
Feb. 23, 2017 06:30 PM EST Reads: 1,720
SYS-CON Media announced today that @WebRTCSummit Blog, the largest WebRTC resource in the world, has been launched. @WebRTCSummit Blog offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. @WebRTCSummit Blog can be bookmarked ▸ Here @WebRTCSummit conference site can be bookmarked ▸ Here
Feb. 23, 2017 06:00 PM EST Reads: 13,040
The Internet of Things can drive efficiency for airlines and airports. In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect with GE, and Sudip Majumder, senior director of development at Oracle, discussed the technical details of the connected airline baggage and related social media solutions. These IoT applications will enhance travelers' journey experience and drive efficiency for the airlines and the airports.
Feb. 23, 2017 06:00 PM EST Reads: 1,498