|By Business Wire||
|July 28, 2014 09:01 AM EDT||
Definiens, the global leader in Tissue Phenomics™ for diagnostics development in oncology, today released tips for the development of diagnostics to help physicians make more informed decisions, reduce unnecessary treatment and improve overall patient health. As the global cost of cancer care continues to rise exponentially, tests based on data generated from the analysis of tissue samples can play a critical role in helping improve stratification to provide patients with effective personalized care.
The overtreatment of cancer represents a significant and complex issue from both a health economics and patient care perspective. Studies published in the New England Journal of Medicine report “the annual direct costs of cancer care are projected to rise from $104 billion in 2006 to over $173 billion in 2020.” The problem, however, is that the current clinical and pathological parameters for diagnosing many cancer-types fail to accurately segment individual patients into specific risk groups. Many patients with low to intermediate stage cancers often receive the same level of aggressive treatment administered to patients with advanced, late-stage cancers. The result? Much of the money is spent on treatments that are unnecessary; leaving many patients needlessly exposed to potentially harmful side effects and long-term health consequences.
“The pervasive problem of cancer overtreatment highlights the urgent need for tests that can improve stratification in order to accurately identify those patient groups that require aggressive treatment, while allowing clinicians to separate out low-risk patients that will benefit from active surveillance,” said Dr. Ralf Huss, Chief Medical Officer of Definiens. “Definiens Tissue Phenomics™ solutions provides researchers with the necessary tools to extract, analyze and correlate all relevant data from heterogeneous tissue samples in order to develop innovative diagnostic tests with the capacity to inform better treatment decisions, lower healthcare costs and meet the needs of individual patients.”
Definiens’ three steps for the development of diagnostics that can reduce unnecessary cancer treatment and improve patient health include:
1. Recognize the Importance of Analyzing Intact Tissue
Over the past decade, advancements in next generation sequencing have proven essential for the molecular subgrouping of patients on the basis of genomic data. However, because there is only partial correlation between gene mutations, gene expression and actual tumor behavior, genomic information alone only provides a first-stage projection of cancer development. Conversely, focusing on the data that resides in intact tissue samples, including the number, shape, size and morphology of different structures and cells and proteins active in and around the tumor, will allow researchers to derive a more precise understanding of tumor biology and identify more effective biomarkers as result.
2. Focus on the Entire Tumor Microenvironment
Among researchers, a focus on genomics has often led to a preoccupation with the tumor itself. However, recent advances in immunotherapy indicate that the development of effective tests that have the ability to determine the likelihood of tumor recurrence and long-term treatment success require image analysis of the entire tumor microenvironment. This includes an understanding of the ways in which cancer cells change and grow in relation to surrounding cellular tissue. Looking at the larger context in which the tumor exists can better inform treatment decisions by providing invaluable insights regarding the probability of cancer progression.
3. Take a Big Data Approach to Tissue Analysis
To be sure, the data that resides in tissue samples is both vast and heterogeneous. Consequently, it is also far too complex and voluminous for human analysis alone. Automated image analysis and data mining that can fully quantify and extract all of the data that resides in tissue samples are critical for the development of tests with real prognostic value. In this regard, a big data approach that allows researchers to correlate information from multiple sources, including complex tissue signatures and genomic profiles, can provide the comprehensive picture needed for superior personalized and targeted treatment decisions.
Definiens is the global leader in Tissue Phenomics™ for discovery and diagnostics development in oncology and provides image analysis solutions for life sciences. Definiens' technology provides detailed tissue biomarker readouts from slide images and enables the correlation of this information with other key clinical or genomic information, an approach known as Tissue Phenomics™. Definiens helps pharmaceutical and biotechnology companies, research institutions, clinical service organizations and pathologists to generate new knowledge and support better decisions in research, diagnostics and therapy.
Definiens’ vision is to open new fields of research, to contribute to development of personalized medicine, and to significantly improve the quality of patients' lives. Definiens is headquartered in Munich, Germany and has its North American headquarters in Carlsbad, CA. Further information is available at www.definiens.com.
“RackN is a software company and we take how a hybrid infrastructure scenario, which consists of clouds, virtualization, traditional data center technologies - how to make them all work together seamlessly from an operational perspective,” stated Dan Choquette, Founder of RackN, in this SYS-CON.tv interview at @DevOpsSummit at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jan. 24, 2017 04:30 PM EST Reads: 3,661
SYS-CON Events announced today that Dataloop.IO, an innovator in cloud IT-monitoring whose products help organizations save time and money, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Dataloop.IO is an emerging software company on the cutting edge of major IT-infrastructure trends including cloud computing and microservices. The company, founded in the UK but now based in San Fran...
Jan. 24, 2017 04:15 PM EST Reads: 2,731
"There's a growing demand from users for things to be faster. When you think about all the transactions or interactions users will have with your product and everything that is between those transactions and interactions - what drives us at Catchpoint Systems is the idea to measure that and to analyze it," explained Leo Vasiliou, Director of Web Performance Engineering at Catchpoint Systems, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York Ci...
Jan. 24, 2017 02:30 PM EST Reads: 5,920
The 20th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held June 6-8, 2017, at the Javits Center in New York City, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal ...
Jan. 24, 2017 02:30 PM EST Reads: 5,393
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
Jan. 24, 2017 02:15 PM EST Reads: 3,278
DevOps is being widely accepted (if not fully adopted) as essential in enterprise IT. But as Enterprise DevOps gains maturity, expands scope, and increases velocity, the need for data-driven decisions across teams becomes more acute. DevOps teams in any modern business must wrangle the ‘digital exhaust’ from the delivery toolchain, "pervasive" and "cognitive" computing, APIs and services, mobile devices and applications, the Internet of Things, and now even blockchain. In this power panel at @...
Jan. 24, 2017 01:45 PM EST Reads: 3,020
20th Cloud Expo, taking place June 6-8, 2017, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy.
Jan. 24, 2017 01:30 PM EST Reads: 4,498
Discover top technologies and tools all under one roof at April 24–28, 2017, at the Westin San Diego in San Diego, CA. Explore the Mobile Dev + Test and IoT Dev + Test Expo and enjoy all of these unique opportunities: The latest solutions, technologies, and tools in mobile or IoT software development and testing. Meet one-on-one with representatives from some of today's most innovative organizations
Jan. 24, 2017 01:00 PM EST Reads: 1,741
SYS-CON Events announced today that Super Micro Computer, Inc., a global leader in Embedded and IoT solutions, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 7-9, 2017, at the Javits Center in New York City, NY. Supermicro (NASDAQ: SMCI), the leading innovator in high-performance, high-efficiency server technology, is a premier provider of advanced server Building Block Solutions® for Data Center, Cloud Computing, Enterprise IT, Hadoop/Big Data, HPC and E...
Jan. 24, 2017 12:45 PM EST Reads: 5,930
@DevOpsSummit taking place June 6-8, 2017 at Javits Center, New York City, is co-located with the 20th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. @DevOpsSummit at Cloud Expo New York Call for Papers is now open.
Jan. 24, 2017 12:30 PM EST Reads: 3,740
SYS-CON Events announced today that Catchpoint Systems, Inc., a provider of innovative web and infrastructure monitoring solutions, has been named “Silver Sponsor” of SYS-CON's DevOps Summit at 18th Cloud Expo New York, which will take place June 7-9, 2016, at the Javits Center in New York City, NY. Catchpoint is a leading Digital Performance Analytics company that provides unparalleled insight into customer-critical services to help consistently deliver an amazing customer experience. Designed ...
Jan. 24, 2017 12:15 PM EST Reads: 6,534
“DevOps is really about the business. The business is under pressure today, competitively in the marketplace to respond to the expectations of the customer. The business is driving IT and the problem is that IT isn't responding fast enough," explained Mark Levy, Senior Product Marketing Manager at Serena Software, in this SYS-CON.tv interview at DevOps Summit, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Jan. 24, 2017 12:15 PM EST Reads: 11,749
More and more brands have jumped on the IoT bandwagon. We have an excess of wearables – activity trackers, smartwatches, smart glasses and sneakers, and more that track seemingly endless datapoints. However, most consumers have no idea what “IoT” means. Creating more wearables that track data shouldn't be the aim of brands; delivering meaningful, tangible relevance to their users should be. We're in a period in which the IoT pendulum is still swinging. Initially, it swung toward "smart for smart...
Jan. 24, 2017 12:00 PM EST Reads: 2,878
The WebRTC Summit New York, to be held June 6-8, 2017, at the Javits Center in New York City, NY, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 20th International Cloud Expo and @ThingsExpo. WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web co...
Jan. 24, 2017 11:45 AM EST Reads: 3,079
"A lot of times people will come to us and have a very diverse set of requirements or very customized need and we'll help them to implement it in a fashion that you can't just buy off of the shelf," explained Nick Rose, CTO of Enzu, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jan. 24, 2017 10:45 AM EST Reads: 4,837