|By Marketwired .||
|July 30, 2014 05:30 AM EDT||
CAMBRIDGE, MA -- (Marketwired) -- 07/30/14 -- Proteostasis Therapeutics, Inc., a company developing novel therapeutics that regulate protein homeostasis to improve outcomes for patients with orphan and neurodegenerative diseases, today announced that it has successfully completed a key preclinical milestone in the collaboration with Biogen Idec. Proteostasis has received a multimillion dollar milestone payment as a result of this achievement.
"We are very encouraged to reach this milestone early in our collaboration with Biogen Idec," said Markus Haeberlein, Ph.D., Chief Scientific Officer at Proteostasis Therapeutics. "Achieving a target protein reduction through inhibition of Usp14 in a whole animal system is an important biological validation and demonstrates the disease-modifying potential of our inhibitors against a variety of neurodegenerative disorders. We look forward to continuing to work with Biogen Idec to bring this program toward candidate designation."
Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, have elevated levels of aggregation-prone proteins in the brain. Prior research has shown that the inhibition of the deubiquinating enzyme, Usp14, enhances proteasome activity and increases the clearance of such proteins.
"We remain optimistic about Usp14 as a very interesting and potentially important target for neurodegeneration," said Spyros Artavanis-Tsakonas, Ph.D., Chief Scientific Officer at Biogen Idec.
In December 2013, Proteostasis and Biogen Idec entered into a collaboration to research and develop therapeutic candidates based on the inhibition of Usp14. Under the agreement, the companies are conducting preclinical research to identify lead compounds for clinical development. At specified points, Proteostasis may opt in for global co-development and U.S. co-commercialization rights. The total deal contains payments of up to $200 million, as well as tiered royalties.
About Proteostasis Therapeutics
Proteostasis Therapeutics is developing disease-modifying therapeutics for cystic fibrosis and neurodegenerative diseases. The Company's technology combines both phenotypic and target based drug discovery to develop therapeutics that modulate protein homeostasis pathways and correct for imbalances in protein folding, trafficking, and clearance. For more information, please visit www.proteostasis.com.
Oct. 4, 2015 09:00 AM EDT Reads: 531
Oct. 4, 2015 09:00 AM EDT Reads: 343
Oct. 4, 2015 09:00 AM EDT Reads: 516
Oct. 4, 2015 08:45 AM EDT Reads: 235
Oct. 4, 2015 08:30 AM EDT Reads: 562
Oct. 4, 2015 08:30 AM EDT Reads: 142
Oct. 4, 2015 08:15 AM EDT Reads: 421
Oct. 4, 2015 08:00 AM EDT Reads: 320
Oct. 4, 2015 08:00 AM EDT Reads: 329
Oct. 4, 2015 08:00 AM EDT Reads: 371
Oct. 4, 2015 08:00 AM EDT Reads: 290
Oct. 4, 2015 08:00 AM EDT Reads: 285
Oct. 4, 2015 07:00 AM EDT Reads: 250
DevOps is speeding towards the IT world like a freight train and the hype around it is deafening. There is no reason to be afraid of this change as it is the natural reaction to the agile movement that revolutionized development just a few years ago. By definition, DevOps is the natural alignment of IT performance to business profitability. The relevance of this has yet to be quantified but it has been suggested that the route to the CEO’s chair will come from the IT leaders that successfully ma...
Oct. 4, 2015 06:00 AM EDT Reads: 14,010
According to Forrester, public cloud platforms are evolving, blurring the lines between Software as a Service (SaaS), Infrastructure as a Service (IaaS), and Platform as a Service (PaaS) in order to satisfy the needs of enterprises and widen their appeal to developers. In The Forrester Wave™: Enterprise Public Cloud Platforms, Q4 2014, Forrester evaluates the 16 most significant Enterprise Public Cloud Platforms and details how each vendor fulfills the 19 evaluation criteria points.
Oct. 4, 2015 05:00 AM EDT Reads: 738