Welcome!

News Feed Item

Colon-MarCarePlex™ Technology is Offered for Sale/License

Plasma RNA biomarker panel for colorectal cancer screening

JERUSALEM, Aug. 1, 2014 /PRNewswire-iReach/ -- Bio-MarCare Technologies, a leader in the development of plasma RNA biomarkers for colorectal cancer (CRC), is offering for sale its proprietary Colon-MarCarePlex™ technology for the pre-cancerous polyps screening in blood. The purchaser will receive all intellectual property (IP) rights, know-how and current business relationships associated with MarCarePlex™ technology.

Breakthrough Blood RNA Biomarkers Push Accurate Colorectal Cancer Screening Test Forward

Circulating free RNAs are considered to be fragile and more susceptible to degradation. We were able to develop a breakthrough reliable and reproducible procedure to purify and stabilize RNA extracted from plasma sufficiently intact to allow analysis by reverse transcription-PCR. RNA biomarker selection process was preformed utilizing a bioinformatics analysis approach along with gene expression array in patient's samples and peer reviews publications. 817 candidate genes were found to be common between the gene array expression analysis and literature data. Top 100 genes which showed the greatest expression levels were tested by qPCR.  Patients were recruited prospectively from 3 clinical sites. For biomarker discovery, plasma RNA was extracted from 3 patient study:  i) Colonoscopy negative individuals;  ii) Advanced adenomatous polyps (pre-cancer) – confirmed by colonoscopy; and iii) Colorectal cancer patients (stages I-III). For the clinical validation trial the intended use screening population is asymptomatic individuals. Thus, the trial will prove that patients can be turned compliant to this screening blood test. 

Eight biomarkers were selected for extensive clinical analysis using 1000 blood samples. Carefully chosen marker combinations formed a solid base to become a sensitive screening assay. A US patent application was filed in light of Supreme Court Prometheus-Mayo decisions and covers multi RNA biomarker panel combination for colorectal cancer screening

Colon-MarCarePlex™: Powerful Biomarker Panels Based on Solid and Proven Technology

The clinical data pinpointed on several leading marker combinations. For Pre-Cancer Predication:  statistical analysis included 46 colonoscopy negative patients and 38 patients with advanced polyp. For a combination model of ID002 with ID005 the ROC analysis and AUC were 70.5%, 95% asymptotic (CI: 58.5%-82.5%), p value <0.001. At Max Youdin Index point performance was sensitivity of 60% and specificity of 87%. These performance characteristics represent the highest accuracy level among other alternatives on market and under development.

A Meaningful Market with Room to Grow

Because patients at earlier stages of CRC are often asymptomatic, CRC screening allows for early identification of cancer at stages where treatment is more likely to be effective. Five-year survival rates for Stages I-II CRC cases are 94% and 82%, respectively. Colon-MarCarePlex assay is a non-inferiority assay for CRC sensitivity when compared to fecal test (FIT) and a superiority test for pre-cancer (advanced polys) sensitivity. Given that identification of pre-cancer is important for reduction of CRC incidence and that detection of CRC at early stages has the potential to significantly reduce mortality, an optimal new screening tool should have high sensitivity for CRC and also capable to identify pre-cancer. BioMarCare high sensitivity in plasma enables screening independently of tumor location and can be with great clinical utility due to patients' compliance.

Bio-Marcare Technologies Ltd. is offering for sale all intellectual property rights and RNA biomarkers panel rights related to its Colon-MarCarePlex™ technology. To learn more about this opportunity, please contact us before August 22th, 2014.

For further information, please contact...

AAD Health, LLC,
Tel: +1-805-791-6696 • Fax: +1-805-498-6867

Media Contact: BioMarCare Technologies Ltd., Biomarcare Technologies Ltd., +972-52-3275719, [email protected]

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

SOURCE BioMarCare Technologies Ltd.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that Loom Systems will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Founded in 2015, Loom Systems delivers an advanced AI solution to predict and prevent problems in the digital business. Loom stands alone in the industry as an AI analysis platform requiring no prior math knowledge from operators, leveraging the existing staff to succeed in the digital era. With offices in S...
With billions of sensors deployed worldwide, the amount of machine-generated data will soon exceed what our networks can handle. But consumers and businesses will expect seamless experiences and real-time responsiveness. What does this mean for IoT devices and the infrastructure that supports them? More of the data will need to be handled at - or closer to - the devices themselves.
DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm.
My team embarked on building a data lake for our sales and marketing data to better understand customer journeys. This required building a hybrid data pipeline to connect our cloud CRM with the new Hadoop Data Lake. One challenge is that IT was not in a position to provide support until we proved value and marketing did not have the experience, so we embarked on the journey ourselves within the product marketing team for our line of business within Progress. In his session at @BigDataExpo, Sum...
The taxi industry never saw Uber coming. Startups are a threat to incumbents like never before, and a major enabler for startups is that they are instantly “cloud ready.” If innovation moves at the pace of IT, then your company is in trouble. Why? Because your data center will not keep up with frenetic pace AWS, Microsoft and Google are rolling out new capabilities In his session at 20th Cloud Expo, Don Browning, VP of Cloud Architecture at Turner, will posit that disruption is inevitable for c...
SYS-CON Events announced today that Telecom Reseller has been named “Media Sponsor” of SYS-CON's 20th International Cloud Expo, which will take place on June 6–8, 2017, at the Javits Center in New York City, NY. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
SYS-CON Events announced today that Ocean9will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Ocean9 provides cloud services for Backup, Disaster Recovery (DRaaS) and instant Innovation, and redefines enterprise infrastructure with its cloud native subscription offerings for mission critical SAP workloads.
Providing the needed data for application development and testing is a huge headache for most organizations. The problems are often the same across companies - speed, quality, cost, and control. Provisioning data can take days or weeks, every time a refresh is required. Using dummy data leads to quality problems. Creating physical copies of large data sets and sending them to distributed teams of developers eats up expensive storage and bandwidth resources. And, all of these copies proliferating...
DevOps is often described as a combination of technology and culture. Without both, DevOps isn't complete. However, applying the culture to outdated technology is a recipe for disaster; as response times grow and connections between teams are delayed by technology, the culture will die. A Nutanix Enterprise Cloud has many benefits that provide the needed base for a true DevOps paradigm. In his Day 3 Keynote at 20th Cloud Expo, Chris Brown, a Solutions Marketing Manager at Nutanix, will explore t...
In recent years, containers have taken the world by storm. Companies of all sizes and industries have realized the massive benefits of containers, such as unprecedented mobility, higher hardware utilization, and increased flexibility and agility; however, many containers today are non-persistent. Containers without persistence miss out on many benefits, and in many cases simply pass the responsibility of persistence onto other infrastructure, adding additional complexity.
SYS-CON Events announced today that Cloudistics, an on-premises cloud computing company, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Cloudistics delivers a complete public cloud experience with composable on-premises infrastructures to medium and large enterprises. Its software-defined technology natively converges network, storage, compute, virtualization, and management into a ...
SYS-CON Events announced today that CA Technologies has been named “Platinum Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY, and the 21st International Cloud Expo®, which will take place October 31-November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. CA Technologies helps customers succeed in a future where every business – from apparel to energy – is being rewritten by software. From ...
Pentaho has announced orchestration capabilities that streamline the entire machine learning workflow and enable teams of data scientists, engineers and analysts to train, tune, test and deploy predictive models. Pentaho’s Data Integration and analytics platform ends the ‘gridlock’ associated with machine learning by enabling smooth team collaboration, maximizing limited data science resources and putting predictive models to work on big data faster – regardless of use case, industry, or languag...
SYS-CON Events announced today that T-Mobile will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. As America's Un-carrier, T-Mobile US, Inc., is redefining the way consumers and businesses buy wireless services through leading product and service innovation. The Company's advanced nationwide 4G LTE network delivers outstanding wireless experiences to 67.4 million customers who are unwilling to compromise on ...
SYS-CON Events announced today that Addteq will exhibit at SYS-CON's DevOps Summit at Cloud Expo, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Addteq specializes in creating innovative solutions to solve business processes through the use of DevOps automation. Addteq was founded on the firm belief that automation is essential for successful software releases. Addteq's products and services are centered around the fundamental approach of understanding the pr...