Welcome!

News Feed Item

Colon-MarCarePlex™ Technology is Offered for Sale/License

Plasma RNA biomarker panel for colorectal cancer screening

JERUSALEM, Aug. 1, 2014 /PRNewswire-iReach/ -- Bio-MarCare Technologies, a leader in the development of plasma RNA biomarkers for colorectal cancer (CRC), is offering for sale its proprietary Colon-MarCarePlex™ technology for the pre-cancerous polyps screening in blood. The purchaser will receive all intellectual property (IP) rights, know-how and current business relationships associated with MarCarePlex™ technology.

Breakthrough Blood RNA Biomarkers Push Accurate Colorectal Cancer Screening Test Forward

Circulating free RNAs are considered to be fragile and more susceptible to degradation. We were able to develop a breakthrough reliable and reproducible procedure to purify and stabilize RNA extracted from plasma sufficiently intact to allow analysis by reverse transcription-PCR. RNA biomarker selection process was preformed utilizing a bioinformatics analysis approach along with gene expression array in patient's samples and peer reviews publications. 817 candidate genes were found to be common between the gene array expression analysis and literature data. Top 100 genes which showed the greatest expression levels were tested by qPCR.  Patients were recruited prospectively from 3 clinical sites. For biomarker discovery, plasma RNA was extracted from 3 patient study:  i) Colonoscopy negative individuals;  ii) Advanced adenomatous polyps (pre-cancer) – confirmed by colonoscopy; and iii) Colorectal cancer patients (stages I-III). For the clinical validation trial the intended use screening population is asymptomatic individuals. Thus, the trial will prove that patients can be turned compliant to this screening blood test. 

Eight biomarkers were selected for extensive clinical analysis using 1000 blood samples. Carefully chosen marker combinations formed a solid base to become a sensitive screening assay. A US patent application was filed in light of Supreme Court Prometheus-Mayo decisions and covers multi RNA biomarker panel combination for colorectal cancer screening

Colon-MarCarePlex™: Powerful Biomarker Panels Based on Solid and Proven Technology

The clinical data pinpointed on several leading marker combinations. For Pre-Cancer Predication:  statistical analysis included 46 colonoscopy negative patients and 38 patients with advanced polyp. For a combination model of ID002 with ID005 the ROC analysis and AUC were 70.5%, 95% asymptotic (CI: 58.5%-82.5%), p value <0.001. At Max Youdin Index point performance was sensitivity of 60% and specificity of 87%. These performance characteristics represent the highest accuracy level among other alternatives on market and under development.

A Meaningful Market with Room to Grow

Because patients at earlier stages of CRC are often asymptomatic, CRC screening allows for early identification of cancer at stages where treatment is more likely to be effective. Five-year survival rates for Stages I-II CRC cases are 94% and 82%, respectively. Colon-MarCarePlex assay is a non-inferiority assay for CRC sensitivity when compared to fecal test (FIT) and a superiority test for pre-cancer (advanced polys) sensitivity. Given that identification of pre-cancer is important for reduction of CRC incidence and that detection of CRC at early stages has the potential to significantly reduce mortality, an optimal new screening tool should have high sensitivity for CRC and also capable to identify pre-cancer. BioMarCare high sensitivity in plasma enables screening independently of tumor location and can be with great clinical utility due to patients' compliance.

Bio-Marcare Technologies Ltd. is offering for sale all intellectual property rights and RNA biomarkers panel rights related to its Colon-MarCarePlex™ technology. To learn more about this opportunity, please contact us before August 22th, 2014.

For further information, please contact...

AAD Health, LLC,
Tel: +1-805-791-6696 • Fax: +1-805-498-6867

Media Contact: BioMarCare Technologies Ltd., Biomarcare Technologies Ltd., +972-52-3275719, [email protected]

News distributed by PR Newswire iReach: https://ireach.prnewswire.com

SOURCE BioMarCare Technologies Ltd.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
The last two years has seen discussions about cloud computing evolve from the public / private / hybrid split to the reality that most enterprises will be creating a complex, multi-cloud strategy. Companies are wary of committing all of their resources to a single cloud, and instead are choosing to spread the risk – and the benefits – of cloud computing across multiple providers and internal infrastructures, as they follow their business needs. Will this approach be successful? How large is the ...
Your clients expect transactions to never fail, cloud access to be fast and always on, and their data to be protected - no exceptions. Hear about how Secure Service Container (SSC), an IBM-exclusive open technology, enables secure building and hosting of next-generation applications, both cloud and on-premises. SSC protects the full stack from external and insider threats, allows automatic encryption of data in-flight and at-rest, and is tamper-resistant during installation and runtime – with no...
With major technology companies and startups seriously embracing Cloud strategies, now is the perfect time to attend 21st Cloud Expo October 31 - November 2, 2017, at the Santa Clara Convention Center, CA, and June 12-14, 2018, at the Javits Center in New York City, NY, and learn what is going on, contribute to the discussions, and ensure that your enterprise is on the right path to Digital Transformation.
SYS-CON Events announced today that B2Cloud will exhibit at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. B2Cloud specializes in IoT devices for preventive and predictive maintenance in any kind of equipment retrieving data like Energy consumption, working time, temperature, humidity, pressure, etc.
SYS-CON Events announced today that Interface Corporation will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Interface Corporation is a company developing, manufacturing and marketing high quality and wide variety of industrial computers and interface modules such as PCIs and PCI express. For more information, visit http://www.i...
SYS-CON Events announced today that Massive Networks, that helps your business operate seamlessly with fast, reliable, and secure internet and network solutions, has been named "Exhibitor" of SYS-CON's 21st International Cloud Expo ®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. As a premier telecommunications provider, Massive Networks is headquartered out of Louisville, Colorado. With years of experience under their belt, their team of...
SYS-CON Events announced today that NetApp has been named “Bronze Sponsor” of SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. NetApp is the data authority for hybrid cloud. NetApp provides a full range of hybrid cloud data services that simplify management of applications and data across cloud and on-premises environments to accelerate digital transformation. Together with their partners, NetApp em...
SYS-CON Events announced today that Mobile Create USA will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Mobile Create USA Inc. is an MVNO-based business model that uses portable communication devices and cellular-based infrastructure in the development, sales, operation and mobile communications systems incorporating GPS capabi...
SYS-CON Events announced today that Nihon Micron will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Nihon Micron Co., Ltd. strives for technological innovation to establish high-density, high-precision processing technology for providing printed circuit board and metal mount RFID tags used for communication devices. For more inf...
SYS-CON Events announced today that N3N will exhibit at SYS-CON's @ThingsExpo, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. N3N’s solutions increase the effectiveness of operations and control centers, increase the value of IoT investments, and facilitate real-time operational decision making. N3N enables operations teams with a four dimensional digital “big board” that consolidates real-time live video feeds alongside IoT sensor data a...
While some developers care passionately about how data centers and clouds are architected, for most, it is only the end result that matters. To the majority of companies, technology exists to solve a business problem, and only delivers value when it is solving that problem. 2017 brings the mainstream adoption of containers for production workloads. In his session at 21st Cloud Expo, Ben McCormack, VP of Operations at Evernote, will discuss how data centers of the future will be managed, how th...
SYS-CON Events announced today that SIGMA Corporation will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. uLaser flow inspection device from the Japanese top share to Global Standard! Then, make the best use of data to flip to next page. For more information, visit http://www.sigma-k.co.jp/en/.
Enterprises are moving to the cloud faster than most of us in security expected. CIOs are going from 0 to 100 in cloud adoption and leaving security teams in the dust. Once cloud is part of an enterprise stack, it’s unclear who has responsibility for the protection of applications, services, and data. When cloud breaches occur, whether active compromise or a publicly accessible database, the blame must fall on both service providers and users. In his session at 21st Cloud Expo, Ben Johnson, C...
SYS-CON Events announced today that Suzuki Inc. will exhibit at the Japan External Trade Organization (JETRO) Pavilion at SYS-CON's 21st International Cloud Expo®, which will take place on Oct 31 – Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Suzuki Inc. is a semiconductor-related business, including sales of consuming parts, parts repair, and maintenance for semiconductor manufacturing machines, etc. It is also a health care business providing experimental research for...
21st International Cloud Expo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Me...