|By PR Newswire||
|August 27, 2014 12:07 PM EDT||
LOS ANGELES, Aug. 27, 2014 /PRNewswire/ -- Lisa Kulik saw fireworks for the first time in nearly 30 years this July 4 holiday, thanks to a groundbreaking retinal implant co-invented by Mark Humayun, M.D., Ph.D., an internationally renowned clinician-researcher at the University of Southern California (USC) Eye Institute.
Kulik is a 55-year-old Peoria, Ariz. resident who has retinitis pigmentosa, a degenerative disease that progressively robs its victims of sight. On June 2, she became the first person west of the Mississippi to receive the FDA-approved Argus II retinal prosthesis, innovative wireless technology co-invented by Humayun, who is the Cornelius Pings Professor of Biomedical Sciences and professor of ophthalmology, biomedical engineering, cell and neurobiology at Keck Medicine of USC and the USC Viterbi School of Engineering.
When Kulik wore the Argus II to the July 4 celebration with her husband and niece, she didn't expect to see anything. But when the fireworks went off, so did flashes in her field of vision.
"My husband and niece were more excited than I was," she said. "I was seeing thick and thin flashes, and I knew it was the fireworks. I've also seen the moon, and I can see the contrast between the grass and the sidewalk.
"I'm hoping I will be able to see silhouettes of people, like my grandchildren, and be able to get around by myself. Losing independence has been the hardest part [of being blind] for me. I'd like to be able to take a walk down the street."
Kulik's progress is encouraging to Humayun, who started developing the Argus II more than 20 years ago.
"She could see spots of light on the first day of activation, which is very exciting," said Humayun, who is professor of ophthalmology and biomedical engineering at USC and co-director of the USC Eye Institute. The USC Eye Institute has ranked as a Top 10 ophthalmology program for 24 years and is No. 3 in research funding from the National Eye Institute. "That put her ahead of our expectations. Most of our patients haven't seen for decades and they have to relearn how to interpret visual signals, which takes quite a while. It's like seeing a baby learn to crawl, then to walk, then to run."
Kulik received the implant during a four-hour surgery at Keck Medicine of USC, performed by Lisa Olmos de Koo, assistant professor of ophthalmology at the Keck School, with Humayun assisting. Kulik is now undergoing several months of follow-up testing while she trains her brain to see in a new way. Some Argus II patients can see contrast well enough to sort light and dark clothing, and to see the outlines of doors, bushes, people and other objects.
The Argus II system uses a camera mounted on special glasses that sends a signal to an electronic receiver with 60 electrodes implanted inside the eye. The receiver sends signals to the retina that travel through the optic nerve to the brain, where they can be interpreted as a visual picture. Future applications of the device are aimed at age-related macular degeneration, a similar but more common disease than RP. The prosthesis is manufactured and sold by Second Sight Medical Products in Sylmar, California.
Clinical trials for the Argus II at USC began in 2007, with more than 30 patients implanted with the device as part of the trial. Eligible patients must be over the age of 25, have little or no light perception in both eyes and have had previous sight.
The Argus II is not just a professional goal for Humayun. As a medical school student, he was inspired to study blindness when complications from diabetes stole his grandmother's sight, and nothing could be done to help her.
"As her vision deteriorated, it was sad to see her losing the enjoyment she got through reading and being in her garden," he said. "That experience made me reconsider my path in medicine, and I obtained a Ph.D. in engineering so I could help restore sight to blind people."
Kulik began losing her sight in her late 20s, and by her early 30s, all she could see were shadows in extremely bright conditions. She had to give up her driver's license and quit her job at a veterinary clinic, working with the animals she loved. And she missed seeing her two sons, now 31 and 24, become men.
Her journey toward sight began in 2012, when her husband Ed saw an article on the Internet about the Argus II. Kulik said Ed's discovery confirmed her continuous optimism that a solution to her blindness would be found.
"When I was diagnosed, I didn't let it stop me," she said. "I knew someone would come up with something."
Innovation is one of the hallmarks of the USC Eye Institute, a leader in National Eye Institute funding and ranked No. 9 in the United States for ophthalmology care by U.S. News & World Report. The Argus II is one of many examples of how the interdisciplinary environment at USC enables the creation of potential miracle solutions to health problems.
"One of USC's strengths is that we have an extraordinarily collaborative environment with world-class expertise in many different areas that can impact our health — including medicine, engineering, pharmacy, interactive media and public policy," said Rohit Varma, M.D., M.P.H., director of the USC Eye Institute and chair, Department of Ophthalmology, Keck School of Medicine of USC. "The Argus II is one of the prime examples of such a collaboration, resulting from a strong relationship with the Keck School of Medicine of USC and the USC Viterbi School of Engineering.
"Losing sight is devastating to most people, making them depressed, more dependent on others and reducing their social interactions and productivity, among other things," Varma added. "Now with the Argus II we have the potential to reverse all that and help people begin new, more independent, productive and fuller lives. By bringing sight back to the blind, the Argus II is truly a miracle."
Retinitis pigmentosa (RP) is a genetic disease affecting nearly 100,000 people in the U.S. Those with the disease experience progressive loss of photoreceptors (rods and cones) or the retinal pigment epithelium, a pigmented cell layer that nourishes retinal cells. As the disease progresses, patients experience night blindness, tunnel vision, blurring, and difficulty adjusting from dark to light environments. Eventually their vision is reduced to shadows and most victims are declared legally blind.
Kulik is also participating in a study to determine whether partial restoration of vision has an impact on how the brain processes information. She returns to USC periodically for magnetic imaging resonation (MRI) tests, as well as testing with the Argus II.
ABOUT USC EYE INSTITUTE:
The USC Eye Institute has consistently ranked as a Top 10 ophthalmology program by U.S. News & World Report and Ophthalmology Times and is No. 3 in research funding from the National Eye Institute. Led by Rohit Varma, M.D., M.P.H., the USC Eye Institute has 21 full-time faculty physicians covering all subspecialties of ophthalmology. The USC Eye Institute is headquartered near downtown Los Angeles and has satellite clinics in Pasadena, Beverly Hills and Arcadia. For more information, go to eye.keckmedicine.org.
ABOUT KECK MEDICINE OF USC
Keck Medicine of USC is the University of Southern California's medical enterprise, one of only two university-based medical systems in the Los Angeles area. Encompassing academic, research and clinical excellence, the medical system attracts internationally renowned experts who teach and practice at the Keck School of Medicine of USC, the region's first medical school; includes the renowned USC Norris Comprehensive Cancer Center, one of the first comprehensive cancer centers established by the National Institutes of Health (NIH) in the United States; has a medical faculty practice, the USC Care Medical Group; operates the Keck Medical Center of USC, which includes two acute care hospitals: 401-licensed bed Keck Hospital of USC and 60-licensed bed USC Norris Cancer Hospital; and owns USC Verdugo Hills Hospital, a 158-licensed bed community hospital. It also includes more than 40 outpatient facilities, some at affiliated hospitals, in Los Angeles, Orange, Kern, Tulare and Ventura counties. For more information, go to www.keckmedicine.org/beyond
Video available at https://www.youtube.com/watch?v=wFUwJZ2aL6I
B-roll available on request
SOURCE Keck Medicine of USC
The speed of software changes in growing and large scale rapid-paced DevOps environments presents a challenge for continuous testing. Many organizations struggle to get this right. Practices that work for small scale continuous testing may not be sufficient as the requirements grow. In his session at DevOps Summit, Marc Hornbeek, Sr. Solutions Architect of DevOps continuous test solutions at Spirent Communications, explained the best practices of continuous testing at high scale, which is rele...
Feb. 22, 2017 03:15 AM EST Reads: 5,443
Feb. 22, 2017 03:00 AM EST Reads: 1,986
Hardware virtualization and cloud computing allowed us to increase resource utilization and increase our flexibility to respond to business demand. Docker Containers are the next quantum leap - Are they?! Databases always represented an additional set of challenges unique to running workloads requiring a maximum of I/O, network, CPU resources combined with data locality.
Feb. 22, 2017 02:45 AM EST Reads: 1,965
"Matrix is an ambitious open standard and implementation that's set up to break down the fragmentation problems that exist in IP messaging and VoIP communication," explained John Woolf, Technical Evangelist at Matrix, in this SYS-CON.tv interview at @ThingsExpo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Feb. 22, 2017 02:00 AM EST Reads: 12,938
"A lot of times people will come to us and have a very diverse set of requirements or very customized need and we'll help them to implement it in a fashion that you can't just buy off of the shelf," explained Nick Rose, CTO of Enzu, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Feb. 22, 2017 01:45 AM EST Reads: 6,005
As software becomes more and more complex, we, as software developers, have been splitting up our code into smaller and smaller components. This is also true for the environment in which we run our code: going from bare metal, to VMs to the modern-day Cloud Native world of containers, schedulers and micro services. While we have figured out how to run containerized applications in the cloud using schedulers, we've yet to come up with a good solution to bridge the gap between getting your contain...
Feb. 22, 2017 01:30 AM EST Reads: 3,489
Feb. 22, 2017 01:30 AM EST Reads: 4,091
"We host and fully manage cloud data services, whether we store, the data, move the data, or run analytics on the data," stated Kamal Shannak, Senior Development Manager, Cloud Data Services, IBM, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Feb. 22, 2017 01:15 AM EST Reads: 5,491
Who are you? How do you introduce yourself? Do you use a name, or do you greet a friend by the last four digits of his social security number? Assuming you don’t, why are we content to associate our identity with 10 random digits assigned by our phone company? Identity is an issue that affects everyone, but as individuals we don’t spend a lot of time thinking about it. In his session at @ThingsExpo, Ben Klang, Founder & President of Mojo Lingo, discussed the impact of technology on identity. Sho...
Feb. 22, 2017 12:30 AM EST Reads: 5,293
Information technology (IT) advances are transforming the way we innovate in business, thereby disrupting the old guard and their predictable status-quo. It’s creating global market turbulence. Industries are converging, and new opportunities and threats are emerging, like never before. So, how are savvy chief information officers (CIOs) leading this transition? Back in 2015, the IBM Institute for Business Value conducted a market study that included the findings from over 1,800 CIO interviews ...
Feb. 22, 2017 12:30 AM EST Reads: 1,611
"Operations is sort of the maturation of cloud utilization and the move to the cloud," explained Steve Anderson, Product Manager for BMC’s Cloud Lifecycle Management, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Feb. 21, 2017 10:45 PM EST Reads: 1,804
Due of the rise of Hadoop, many enterprises are now deploying their first small clusters of 10 to 20 servers. At this small scale, the complexity of operating the cluster looks and feels like general data center servers. It is not until the clusters scale, as they inevitably do, when the pain caused by the exponential complexity becomes apparent. We've seen this problem occur time and time again. In his session at Big Data Expo, Greg Bruno, Vice President of Engineering and co-founder of StackIQ...
Feb. 21, 2017 10:00 PM EST Reads: 8,762
"I think that everyone recognizes that for IoT to really realize its full potential and value that it is about creating ecosystems and marketplaces and that no single vendor is able to support what is required," explained Esmeralda Swartz, VP, Marketing Enterprise and Cloud at Ericsson, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Feb. 21, 2017 09:45 PM EST Reads: 653
The buzz continues for cloud, data analytics and the Internet of Things (IoT) and their collective impact across all industries. But a new conversation is emerging - how do companies use industry disruption and technology enablers to lead in markets undergoing change, uncertainty and ambiguity? Organizations of all sizes need to evolve and transform, often under massive pressure, as industry lines blur and merge and traditional business models are assaulted and turned upside down. In this new da...
Feb. 21, 2017 09:30 PM EST Reads: 698
Bert Loomis was a visionary. This general session will highlight how Bert Loomis and people like him inspire us to build great things with small inventions. In their general session at 19th Cloud Expo, Harold Hannon, Architect at IBM Bluemix, and Michael O'Neill, Strategic Business Development at Nvidia, discussed the accelerating pace of AI development and how IBM Cloud and NVIDIA are partnering to bring AI capabilities to "every day," on-demand. They also reviewed two "free infrastructure" pr...
Feb. 21, 2017 09:15 PM EST Reads: 680