Welcome!

News Feed Item

USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States

Keck Medicine of USC patient sees for first time in 30 years only one week after implant

LOS ANGELES, Aug. 27, 2014 /PRNewswire/ -- Lisa Kulik saw fireworks for the first time in nearly 30 years this July 4 holiday, thanks to a groundbreaking retinal implant co-invented by Mark Humayun, M.D., Ph.D., an internationally renowned clinician-researcher at the University of Southern California (USC) Eye Institute.

Kulik is a 55-year-old Peoria, Ariz. resident who has retinitis pigmentosa, a degenerative disease that progressively robs its victims of sight. On June 2, she became the first person west of the Mississippi to receive the FDA-approved Argus II retinal prosthesis, innovative wireless technology co-invented by Humayun, who is the Cornelius Pings Professor of Biomedical Sciences and professor of ophthalmology, biomedical engineering, cell and neurobiology at Keck Medicine of USC and the USC Viterbi School of Engineering.

When Kulik wore the Argus II to the July 4 celebration with her husband and niece, she didn't expect to see anything. But when the fireworks went off, so did flashes in her field of vision.

"My husband and niece were more excited than I was," she said. "I was seeing thick and thin flashes, and I knew it was the fireworks. I've also seen the moon, and I can see the contrast between the grass and the sidewalk.

"I'm hoping I will be able to see silhouettes of people, like my grandchildren, and be able to get around by myself. Losing independence has been the hardest part [of being blind] for me. I'd like to be able to take a walk down the street."

Kulik's progress is encouraging to Humayun, who started developing the Argus II more than 20 years ago.

"She could see spots of light on the first day of activation, which is very exciting," said Humayun, who is professor of ophthalmology and biomedical engineering at USC and co-director of the USC Eye Institute. The USC Eye Institute has ranked as a Top 10 ophthalmology program for 24 years and is No. 3 in research funding from the National Eye Institute. "That put her ahead of our expectations. Most of our patients haven't seen for decades and they have to relearn how to interpret visual signals, which takes quite a while. It's like seeing a baby learn to crawl, then to walk, then to run."

Kulik received the implant during a four-hour surgery at Keck Medicine of USC, performed by Lisa Olmos de Koo, assistant professor of ophthalmology at the Keck School, with Humayun assisting. Kulik is now undergoing several months of follow-up testing while she trains her brain to see in a new way. Some Argus II patients can see contrast well enough to sort light and dark clothing, and to see the outlines of doors, bushes, people and other objects.

The Argus II system uses a camera mounted on special glasses that sends a signal to an electronic receiver with 60 electrodes implanted inside the eye. The receiver sends signals to the retina that travel through the optic nerve to the brain, where they can be interpreted as a visual picture. Future applications of the device are aimed at age-related macular degeneration, a similar but more common disease than RP. The prosthesis is manufactured and sold by Second Sight Medical Products in Sylmar, California.

Clinical trials for the Argus II at USC began in 2007, with more than 30 patients implanted with the device as part of the trial. Eligible patients must be over the age of 25, have little or no light perception in both eyes and have had previous sight.

The Argus II is not just a professional goal for Humayun. As a medical school student, he was inspired to study blindness when complications from diabetes stole his grandmother's sight, and nothing could be done to help her.

"As her vision deteriorated, it was sad to see her losing the enjoyment she got through reading and being in her garden," he said. "That experience made me reconsider my path in medicine, and I obtained a Ph.D. in engineering so I could help restore sight to blind people."

Kulik began losing her sight in her late 20s, and by her early 30s, all she could see were shadows in extremely bright conditions. She had to give up her driver's license and quit her job at a veterinary clinic, working with the animals she loved. And she missed seeing her two sons, now 31 and 24, become men.

Her journey toward sight began in 2012, when her husband Ed saw an article on the Internet about the Argus II.  Kulik said Ed's discovery confirmed her continuous optimism that a solution to her blindness would be found.

"When I was diagnosed, I didn't let it stop me," she said. "I knew someone would come up with something."

Innovation is one of the hallmarks of the USC Eye Institute, a leader in National Eye Institute funding and ranked No. 9 in the United States for ophthalmology care by U.S. News & World Report. The Argus II is one of many examples of how the interdisciplinary environment at USC enables the creation of potential miracle solutions to health problems.

"One of USC's strengths is that we have an extraordinarily collaborative environment with world-class expertise in many different areas that can impact our health — including medicine, engineering, pharmacy, interactive media and public policy," said Rohit Varma, M.D., M.P.H., director of the USC Eye Institute and chair, Department of Ophthalmology, Keck School of Medicine of USC. "The Argus II is one of the prime examples of such a collaboration, resulting from a strong relationship with the Keck School of Medicine of USC and the USC Viterbi School of Engineering. 

"Losing sight is devastating to most people, making them depressed, more dependent on others and reducing their social interactions and productivity, among other things," Varma added. "Now with the Argus II we have the potential to reverse all that and help people begin new, more independent, productive and fuller lives. By bringing sight back to the blind, the Argus II is truly a miracle."

Retinitis pigmentosa (RP) is a genetic disease affecting nearly 100,000 people in the U.S. Those with the disease experience progressive loss of photoreceptors (rods and cones) or the retinal pigment epithelium, a pigmented cell layer that nourishes retinal cells. As the disease progresses, patients experience night blindness, tunnel vision, blurring, and difficulty adjusting from dark to light environments. Eventually their vision is reduced to shadows and most victims are declared legally blind.

Kulik is also participating in a study to determine whether partial restoration of vision has an impact on how the brain processes information. She returns to USC periodically for magnetic imaging resonation (MRI) tests, as well as testing with the Argus II.

ABOUT USC EYE INSTITUTE:
The USC Eye Institute has consistently ranked as a Top 10 ophthalmology program by U.S. News & World Report and Ophthalmology Times and is No. 3 in research funding from the National Eye Institute. Led by Rohit Varma, M.D., M.P.H., the USC Eye Institute has 21 full-time faculty physicians covering all subspecialties of ophthalmology. The USC Eye Institute is headquartered near downtown Los Angeles and has satellite clinics in Pasadena, Beverly Hills and Arcadia. For more information, go to eye.keckmedicine.org.

ABOUT KECK MEDICINE OF USC
Keck Medicine of USC is the University of Southern California's medical enterprise, one of only two university-based medical systems in the Los Angeles area. Encompassing academic, research and clinical excellence, the medical system attracts internationally renowned experts who teach and practice at the Keck School of Medicine of USC, the region's first medical school; includes the renowned USC Norris Comprehensive Cancer Center, one of the first comprehensive cancer centers established by the National Institutes of Health (NIH) in the United States; has a medical faculty practice, the USC Care Medical Group; operates the Keck Medical Center of USC, which includes two acute care hospitals: 401-licensed bed Keck Hospital of USC and 60-licensed bed USC Norris Cancer Hospital; and owns USC Verdugo Hills Hospital, a 158-licensed bed community hospital. It also includes more than 40 outpatient facilities, some at affiliated hospitals, in Los Angeles, Orange, Kern, Tulare and Ventura counties. For more information, go to www.keckmedicine.org/beyond

Video available at https://www.youtube.com/watch?v=wFUwJZ2aL6I

B-roll available on request

University of Southern California logo.

SOURCE Keck Medicine of USC

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
SYS-CON Events announced today that Isomorphic Software will exhibit at DevOps Summit at 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Isomorphic Software provides the SmartClient HTML5/AJAX platform, the most advanced technology for building rich, cutting-edge enterprise web applications for desktop and mobile. SmartClient combines the productivity and performance of traditional desktop software with the simp...
Today we can collect lots and lots of performance data. We build beautiful dashboards and even have fancy query languages to access and transform the data. Still performance data is a secret language only a couple of people understand. The more business becomes digital the more stakeholders are interested in this data including how it relates to business. Some of these people have never used a monitoring tool before. They have a question on their mind like “How is my application doing” but no id...
Actian Corporation has announced the latest version of the Actian Vector in Hadoop (VectorH) database, generally available at the end of July. VectorH is based on the same query engine that powers Actian Vector, which recently doubled the TPC-H benchmark record for non-clustered systems at the 3000GB scale factor (see tpc.org/3323). The ability to easily ingest information from different data sources and rapidly develop queries to make better business decisions is becoming increasingly importan...
SYS-CON Events announced today that 910Telecom will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Housed in the classic Denver Gas & Electric Building, 910 15th St., 910Telecom is a carrier-neutral telecom hotel located in the heart of Denver. Adjacent to CenturyLink, AT&T, and Denver Main, 910Telecom offers connectivity to all major carriers, Internet service providers, Internet backbones and ...
Kubernetes, Docker and containers are changing the world, and how companies are deploying their software and running their infrastructure. With the shift in how applications are built and deployed, new challenges must be solved. In his session at @DevOpsSummit at19th Cloud Expo, Sebastian Scheele, co-founder of Loodse, will discuss the implications of containerized applications/infrastructures and their impact on the enterprise. In a real world example based on Kubernetes, he will show how to ...
Traditional on-premises data centers have long been the domain of modern data platforms like Apache Hadoop, meaning companies who build their business on public cloud were challenged to run Big Data processing and analytics at scale. But recent advancements in Hadoop performance, security, and most importantly cloud-native integrations, are giving organizations the ability to truly gain value from all their data. In his session at 19th Cloud Expo, David Tishgart, Director of Product Marketing ...
As the world moves toward more DevOps and Microservices, application deployment to the cloud ought to become a lot simpler. The Microservices architecture, which is the basis of many new age distributed systems such as OpenStack, NetFlix and so on, is at the heart of Cloud Foundry - a complete developer-oriented Platform as a Service (PaaS) that is IaaS agnostic and supports vCloud, OpenStack and AWS. Serverless computing is revolutionizing computing. In his session at 19th Cloud Expo, Raghav...
SYS-CON Events announced today Telecom Reseller has been named “Media Sponsor” of SYS-CON's 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Telecom Reseller reports on Unified Communications, UCaaS, BPaaS for enterprise and SMBs. They report extensively on both customer premises based solutions such as IP-PBX as well as cloud based and hosted platforms.
Aspose.Total for .NET is the most complete package of all file format APIs for .NET as offered by Aspose. It empowers developers to create, edit, render, print and convert between a wide range of popular document formats within any .NET, C#, ASP.NET and VB.NET applications. Aspose compiles all .NET APIs on a daily basis to ensure that it contains the most up to date versions of each of Aspose .NET APIs. If a new .NET API or a new version of existing APIs is released during the subscription peri...
SYS-CON Events announced today that StarNet Communications will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. StarNet Communications’ FastX is the industry first cloud-based remote X Windows emulator. Using standard Web browsers (FireFox, Chrome, Safari, etc.) users from around the world gain highly secure access to applications and data hosted on Linux-based servers in a central data center. ...
Smart Cities are here to stay, but for their promise to be delivered, the data they produce must not be put in new siloes. In his session at @ThingsExpo, Mathias Herberts, Co-founder and CTO of Cityzen Data, will deep dive into best practices that will ensure a successful smart city journey.
DevOps at Cloud Expo, taking place Nov 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long dev...
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
StarNet Communications Corp has announced the addition of three Secure Remote Desktop modules to its flagship X-Win32 PC X server. The new modules enable X-Win32 to safely tunnel the remote desktops from Linux and Unix servers to the user’s PC over encrypted SSH. Traditionally, users of PC X servers deploy the XDMCP protocol to display remote desktop environments such as the Gnome and KDE desktops on Linux servers and the CDE environment on Solaris Unix machines. XDMCP is used primarily on comp...
There is growing need for data-driven applications and the need for digital platforms to build these apps. In his session at 19th Cloud Expo, Muddu Sudhakar, VP and GM of Security & IoT at Splunk, will cover different PaaS solutions and Big Data platforms that are available to build applications. In addition, AI and machine learning are creating new requirements that developers need in the building of next-gen apps. The next-generation digital platforms have some of the past platform needs a...