|By PR Newswire||
|September 4, 2014 11:22 AM EDT||
DIEPENBEEK, Belgium, September 4, 2014 /PRNewswire/ --
Scientists discover how to 'switch off' autoimmune diseases
Apitope, the drug discovery and development company focused on disease-modifying treatments for patients with autoimmune and allergic diseases, announced today that Bristol University research led by Apitope Founder and CSO, Prof David Wraith, on its treatment approach to autoimmune diseases, such as Multiple Sclerosis (MS), has been published in Nature Communications.
The researchers at the University of Bristol reported an important breakthrough in the fight against debilitating autoimmune diseases such as Multiple Sclerosis. Rather than the body's immune system destroying its own tissue by mistake, researchers have discovered how cells convert from being aggressive to actually protecting against disease. It's hoped this latest insight will lead to the widespread use of antigen-specific immunotherapy as a treatment for many autoimmune disorders, including Multiple Sclerosis (MS), Factor VIII intolerance in haemophiliacs, Graves' disease (hyperthyroidism) and uveitis, conditions for which Apitope is developing important new therapies.
Commenting on the research, Dr. Keith Martin, CEO said: "Multiple Sclerosis affects around 100,000 people in the UK and 2.5 million people worldwide. This is an important breakthrough in our fight against debilitating autoimmune diseases by providing further important information on how to stop cells attacking healthy body tissue. This research further reinforces Apitope's treatment approach, which has already successfully completed two clinical trials in MS patients with MRI data showing a significant decrease in new lesions, and has the potential to improve the lives of millions of people worldwide. Importantly, we are now taking this approach into other serious autoimmune conditions as well as MS."
The reported study, funded by the Wellcome Trust, is published in Nature Communications. The article entitled "Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy" that describes how researchers have managed to "switch off" autoimmune disease as a breakthrough for Multiple Sclerosis (MS) treatment, can be viewed here: http://www.nature.com/ncomms/2014/140903/ncomms5741/full/ncomms5741.html
Apitope International NV, based in Belgium and the UK, is a world-class drug developer of immunotherapies for the treatment of autoimmune and allergic diseases, including multiple sclerosis, factor VIII intolerance, uveitis and Graves' disease. The Company has a patented discovery platform which enables selection of potential disease-modifying peptide therapies for the autoimmune/allergic disease of interest; and has already generated a pipeline of 7 programmes in clinical and preclinical development, of which the lead programme in multiple sclerosis is partnered with Merck Serono. The discovery engine selects Apitopes® - Antigen Processing Independent epiTOPES. Apitopes® are soluble, synthetic peptides from the human sequence which can selectively suppress abnormal immune responses and reinstate the normal immune balance (Larche M, Wraith DC. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2005;11:S69-76). Stakeholders in the company include the Wellcome Trust, LRM, Vesalius Biocapital and the US MS charity, Fast Forward. For more information on the company, please visit: http://www.apitope.com.
For further information:
Apitope International N.V.
Dr. Keith Martin, CEO
Mary Clark, Supriya Mathur, Hollie Vile
Feb. 21, 2017 02:30 PM EST Reads: 1,281
Feb. 21, 2017 02:15 PM EST Reads: 397
Feb. 21, 2017 01:45 PM EST Reads: 3,542
Feb. 21, 2017 01:45 PM EST Reads: 427
Feb. 21, 2017 01:30 PM EST Reads: 719
Feb. 21, 2017 01:30 PM EST Reads: 1,054
Feb. 21, 2017 01:15 PM EST Reads: 1,221
Feb. 21, 2017 01:15 PM EST Reads: 1,384
Feb. 21, 2017 01:15 PM EST Reads: 1,181
Feb. 21, 2017 12:45 PM EST Reads: 683
Security, data privacy, reliability and regulatory compliance are critical factors when evaluating whether to move business applications from in-house client hosted environments to a cloud platform. In her session at 18th Cloud Expo, Vandana Viswanathan, Associate Director at Cognizant, In this session, will provide an orientation to the five stages required to implement a cloud hosted solution validation strategy.
Feb. 21, 2017 12:45 PM EST Reads: 4,513
Feb. 21, 2017 12:45 PM EST Reads: 760
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, whic...
Feb. 21, 2017 12:30 PM EST Reads: 583
Cloud Expo, Inc. has announced today that Aruna Ravichandran, vice president of DevOps Product and Solutions Marketing at CA Technologies, has been named co-conference chair of DevOps at Cloud Expo 2017. The @DevOpsSummit at Cloud Expo New York will take place on June 6-8, 2017, at the Javits Center in New York City, New York, and @DevOpsSummit at Cloud Expo Silicon Valley will take place Oct. 31-Nov. 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA.
Feb. 21, 2017 12:30 PM EST Reads: 1,151
With 10 simultaneous tracks, keynotes, general sessions and targeted breakout classes, Cloud Expo and @ThingsExpo are two of the most important technology events of the year. Since its launch over eight years ago, Cloud Expo and @ThingsExpo have presented a rock star faculty as well as showcased hundreds of sponsors and exhibitors! In this blog post, I provide 7 tips on how, as part of our world-class faculty, you can deliver one of the most popular sessions at our events. But before reading the...
Feb. 21, 2017 12:30 PM EST Reads: 7,964