News Feed Item
CORRECTING and REPLACING Xcell Biosciences Initiates New Collaborations with UCSF Researchers Studying Effectiveness of Immunotherapy in Urologic Cancers
|By Business Wire
|September 22, 2016 12:12 PM EDT
Please replace the release with the following corrected version due to
The corrected release reads:
XCELL BIOSCIENCES INITIATES NEW COLLABORATIONS WITH UCSF RESEARCHERS
STUDYING EFFECTIVENESS OF IMMUNOTHERAPY IN UROLOGIC CANCERS
Studies Assess the Ability to Predict Prognosis and Response to
Therapies by Immunoprofiling of Patients’ Blood, Cultured and
Conditioned with Xcell’s Unique Avatar System
Xcell Biosciences, Inc., announced today that it has extended its
collaborative work with the University of California, San Francisco
(UCSF) to include working with three principal investigators on pilot
studies using Xcell’s Avatar cell culture system and proprietary
analytics platform. The work will determine if large scale RNA profiling
from peripheral blood and other patient-derived sample sources cultured
in the Avatar System and correlated to clinical outcomes can predict a
patient’s response to first or second line treatments in prostate,
bladder and kidney cancers.
Charles J. Ryan, MD, Professor of Clinical Medicine and Urology and the
Clinical Program Leader for Genitourinary Medical Oncology at the UCSF
Helen Diller Family Comprehensive Cancer Center, has been collaborating
with Xcell for several years on a number of projects. The latest
involves studying the relationship between genomic variation in prostate
cancer patient samples and response to treatment, including in patients
who have developed resistance to standard of care therapies.
“We are particularly enthusiastic about the opportunity to use the
Avatar system to compare results from liquid biopsies to actual tissue
biopsies,” said Dr. Ryan. “We also are optimistic about the ability to
use the system to look at broad-scale genomic alterations in cancer
patients without the necessity for looking at circulating tumor cells,
cell free DNA or tissue biopsies. Xcell’s system offers the opportunity
to look at different types of analysis all with one blood draw – for
example, potential relationships between immunology, androgen receptors,
and DNA repair in prostate cancer.”
Terry Friedlander, MD, Associate Clinical Professor of Medicine at UCSF,
is collaborating on studies involving prostate and bladder cancer. “We
are excited about this collaboration and the potential ability to use
the Avatar system as an immunologic springboard,” he said. “Predicting
treatment response is a huge unanswered question in oncology in general.
If the Avatar system can keep the cells in the same state that they were
in the body, we may get a more accurate read on the activation status of
the immune system and determine markers that might help predict response
UCSF medical oncologist Won Kim, MD, who is leading a study in kidney
cancer, added: “Kidney cancer is a disease where we have a real shortage
of predictive and prognostic biomarkers. For this pilot study, we’re
hopeful that we will show that the data generated from Xcell’s platform
will help us identify which patients with renal cell cancer are more
likely to respond to tyrosine kinase inhibitors or immunotherapy. We all
want these feasibility studies to succeed because there are so many
cancers where tissue is just not easy to access.”
James Lim, PhD, Chief Scientific Officer at Xcell Biosciences,
commented, “We are delighted to continue our collaborative work with
UCSF, a leading center for cancer clinical research, on these new
studies. We believe our RNA-based whole transcriptome approach to liquid
biopsy will enable us to generate unique gene expression signatures that
will predict a patient’s response to a given therapeutic. Our goal is to
ultimately demonstrate evidence that the Avatar system’s physiologically
relevant microenvironments can provide unparalleled and previously
unavailable diagnostic insights enabling oncologists to treat patients
more effectively and also at the right time.”
About the Avatar System
The Avatar system, including a benchtop and stackable instrument and
consumables for a number of applications, enables a new generation of
cell-based assays by allowing for complete control of key physiological
conditions found in the microenvironments of cells, including settings
for pressure, oxygen, temperature and CO2 levels. In addition to
enabling culture of difficult samples such as tumor biopsies and primary
samples, the system overcomes limitations of traditional cell culture to
generate results that exhibit the phenotypic, genomic and proteomic
characteristics of the native sample.
For more information, visit www.xcellbio.com.
About Xcell Biosciences, Inc.
Xcell Biosciences, Inc., is developing revolutionary products and
workflows for life science and translational research that reproduce
physiologically relevant conditions to enable more meaningful,
biologically relevant experiments. The company’s tools empower
scientists to obtain accurate and actionable results in important fields
such as cancer research, biomarker discovery, lead candidate selection
and optimization, stem cell research and regenerative medicine, and
immunotherapy drug development. Xcell’s first product, the Avatar™
system, opens the door for a new generation of cell-based assays by
allowing for complete control of key physiological conditions found in
cellular microenvironments. In addition to enabling culture of difficult
samples such as tumor biopsies and primary samples, the system overcomes
limitations of traditional cell culture to generate results that exhibit
the phenotypic, genomic and proteomic characteristics of the native
sample. Based in San Francisco, Xcell Biosciences has raised more than
$5M from Viking Global, DST Global, Lightspeed Venture Partners, and HBM
Genomics, as well as a number of other angel investors and funds.
View source version on businesswire.com: http://www.businesswire.com/news/home/20160922005319/en/
SYS-CON Events announced today the Enterprise IoT Bootcamp, being held November 1-2, 2016, in conjunction with 19th Cloud Expo | @ThingsExpo at the Santa Clara Convention Center in Santa Clara, CA.
Combined with real-world scenarios and use cases, the Enterprise IoT Bootcamp is not just based on presentations but with hands-on demos and detailed walkthroughs. We will introduce you to a variety of real world use cases prototyped using Arduino, Raspberry Pi, BeagleBone, Spark, and Intel Edison. Y...
Sep. 27, 2016 09:30 PM EDT Reads: 2,945
Complete Internet of Things (IoT) embedded device security is not just about the device but involves the entire product’s identity, data and control integrity, and services traversing the cloud. A device can no longer be looked at as an island; it is a part of a system. In fact, given the cross-domain interactions enabled by IoT it could be a part of many systems. Also, depending on where the device is deployed, for example, in the office building versus a factory floor or oil field, security ha...
Sep. 27, 2016 09:30 PM EDT Reads: 440
Is your aging software platform suffering from technical debt while the market changes and demands new solutions at a faster clip?
It’s a bold move, but you might consider walking away from your core platform and starting fresh. ReadyTalk did exactly that.
In his General Session at 19th Cloud Expo, Michael Chambliss, Head of Engineering at ReadyTalk, will discuss why and how ReadyTalk diverted from healthy revenue and over a decade of audio conferencing product development to start an innovati...
Sep. 27, 2016 08:30 PM EDT Reads: 2,032
Fifty billion connected devices and still no winning protocols standards. HTTP, WebSockets, MQTT, and CoAP seem to be leading in the IoT protocol race at the moment but many more protocols are getting introduced on a regular basis. Each protocol has its pros and cons depending on the nature of the communications. Does there really need to be only one protocol to rule them all? Of course not.
In his session at @ThingsExpo, Chris Matthieu, co-founder and CTO of Octoblu, walk you through how Oct...
Sep. 27, 2016 08:15 PM EDT Reads: 2,226
The Jevons Paradox suggests that when technological advances increase efficiency of a resource, it results in an overall increase in consumption. Writing on the increased use of coal as a result of technological improvements, 19th-century economist William Stanley Jevons found that these improvements led to the development of new ways to utilize coal.
In his session at 19th Cloud Expo, Mark Thiele, Chief Strategy Officer for Apcera, will compare the Jevons Paradox to modern-day enterprise IT, e...
Sep. 27, 2016 07:30 PM EDT Reads: 2,145
SYS-CON Events announced today that Bsquare has been named “Silver Sponsor” of SYS-CON's @ThingsExpo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
For more than two decades, Bsquare has helped its customers extract business value from a broad array of physical assets by making them intelligent, connecting them, and using the data they generate to optimize business processes.
Sep. 27, 2016 07:00 PM EDT Reads: 2,854
Whether they’re located in a public, private, or hybrid cloud environment, cloud technologies are constantly evolving. While the innovation is exciting, the end mission of delivering business value and rapidly producing incremental product features is paramount.
In his session at @DevOpsSummit at 19th Cloud Expo, Kiran Chitturi, CTO Architect at Sungard AS, will discuss DevOps culture, its evolution of frameworks and technologies, and how it is achieving maturity. He will also cover various st...
Sep. 27, 2016 06:45 PM EDT Reads: 1,815
Identity is in everything and customers are looking to their providers to ensure the security of their identities, transactions and data. With the increased reliance on cloud-based services, service providers must build security and trust into their offerings, adding value to customers and improving the user experience. Making identity, security and privacy easy for customers provides a unique advantage over the competition.
Sep. 27, 2016 06:30 PM EDT Reads: 3,564
There are several IoTs: the Industrial Internet, Consumer Wearables, Wearables and Healthcare, Supply Chains, and the movement toward Smart Grids, Cities, Regions, and Nations. There are competing communications standards every step of the way, a bewildering array of sensors and devices, and an entire world of competing data analytics platforms. To some this appears to be chaos.
In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Bradley Holt, Developer Advocate a...
Sep. 27, 2016 06:30 PM EDT Reads: 2,200
SYS-CON Events announced today that Niagara Networks will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Niagara Networks offers the highest port-density systems, and the most complete Next-Generation Network Visibility systems including Network Packet Brokers, Bypass Switches, and Network TAPs.
Sep. 27, 2016 06:15 PM EDT Reads: 396
SYS-CON Events announced today that Secure Channels will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
The bedrock of Secure Channels Technology is a uniquely modified and enhanced process based on superencipherment. Superencipherment is the process of encrypting an already encrypted message one or more times, either using the same or a different algorithm.
Sep. 27, 2016 06:00 PM EDT Reads: 1,700
If you’re responsible for an application that depends on the data or functionality of various IoT endpoints – either sensors or devices – your brand reputation depends on the security, reliability, and compliance of its many integrated parts. If your application fails to deliver the expected business results, your customers and partners won't care if that failure stems from the code you developed or from a component that you integrated. What can you do to ensure that the endpoints work as expect...
Sep. 27, 2016 05:45 PM EDT Reads: 1,662
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls?
In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, provided tips on how to be successful in large scale machine learning...
Sep. 27, 2016 05:30 PM EDT Reads: 2,025
If you had a chance to enter on the ground level of the largest e-commerce market in the world – would you? China is the world’s most populated country with the second largest economy and the world’s fastest growing market. It is estimated that by 2018 the Chinese market will be reaching over $30 billion in gaming revenue alone.
Admittedly for a foreign company, doing business in China can be challenging. Often changing laws, administrative regulations and the often inscrutable Chinese Interne...
Sep. 27, 2016 05:15 PM EDT Reads: 313
In his general session at 18th Cloud Expo, Lee Atchison, Principal Cloud Architect and Advocate at New Relic, discussed cloud as a ‘better data center’ and how it adds new capacity (faster) and improves application availability (redundancy). The cloud is a ‘Dynamic Tool for Dynamic Apps’ and resource allocation is an integral part of your application architecture, so use only the resources you need and allocate /de-allocate resources on the fly.
Sep. 27, 2016 05:15 PM EDT Reads: 2,769