Welcome!

News Feed Item

Replicor divulga a realização de um ano de controle funcional do HBV e HDV com NAPs, além de novas percepções mecânicas em farmacologia com o NAP

Replicor Inc., uma empresa farmacêutica de capital privado, que tem como objetivo uma cura para a infecção crônica por HBV e HDV (hepatites B e D), divulgou hoje novos dados significativos na atividade dos NAPs (neurolépticos de ação prolongada ou antipsicóticos) em infecções por HBV e HDV no encontro anual da Associação Europeia para o Estudo do Fígado (EASL), que ocorre de 19 a 23 de abril de 2017 em Amsterdã, na Holanda.

Atualizações nos estudos REP 301 (coinfecção por HBV/HDV) e REP 401 (infecção por HBV) demonstraram avanços importantes:

1. No estudo REP 301, o controle funcional relatado anteriormente às 24 semanas de acompanhamento do HBV (5/12 pacientes) e HDV (7/12 pacientes) manteve-se por um ano, demonstrando a durabilidade do controle funcional estabelecido com a terapia com base em NAPs (pôster LBP-507).

2. No estudo REP 401, 30 pacientes receberam pelo menos 12 semanas de exposição aos NAPs e a resposta do HBsAg sérico ao longo do tempo continua a melhorar: as reduções atuais de linha de base apresentadas foram de > 1 log em 29 pacientes, > 2 logs em 25 pacientes, > 4 logs em 19 pacientes, com perda de HBsAg em 14 pacientes. A melhoria da eficácia do pegIFN (produção de anti-HBs marcados e/ou exacerbações de transaminase terapêutica) ocorreu em todos os doentes com uma redução de HBsAg> 4 logs (pôster THU-154).

3. Surpreendentemente, a análise do HBsAg, HBeAg, HBcrAg, RNA de HBV, DNA de HBV e RNA de HDV séricos, em ambos os estudos, indicou que o HBsAg circulante parece ser quase completamente derivado da integração.

“A noção de que quase todo o HBsAg circulante é derivado da integração tem importantes implicações terapêuticas”, disse o diretor científico, Dr. Andrew Vaillant. “Como o principal agente imunossupressor nas infecções por HBV e HDV, a remoção do HBsAg será crítica. É muito provável que os novos agentes de investigação com outros mecanismos antivirais ainda exijam agentes que direcionem diretamente a liberação de HBsAg, como os NAPs, para se alcançar uma taxa elevada de controle funcional.” Dr. Bazinet, o diretor executivo, acrescentou: “Nossos dados clínicos continuamente em expansão continuam a demonstrar que taxas significativas de controle funcional do HBV e HDV podem ser alcançadas com os medicamentos atualmente aprovados e os NAPs”.

A sequenciação profunda do HBsAg no estudo REP 102 anterior não demonstrou pressão de seleção com o REP 2139, validando ainda a resposta do HBsAg sérico à terapia com NAP (pôster THU-155). Um sistema de cultura de tecidos recentemente desenvolvido reproduz pela primeira vez os efeitos pós-entrada dos NAPs sobre a secreção de partículas de HBV observadas pré-clinicamente e clinicamente (pôster THU-156).

Dr. Vaillant observou: “A capacidade de se modelar os efeitos pós-entrada dos NAPs em cultura de tecidos é a culminação de mais de 6 anos de trabalho, o que inclui vários colaboradores no mundo inteiro. Com este recurso finalmente disponível, os mecanismos hospedeiros almejados pelos NAPs podem agora começar a ser explorados”.

As apresentações da Replicor no EASL 2017 estão disponíveis agora em www.replicor.com/science/conference-presentations. Para o encontro EASL 2017: https://ilc-congress.eu/.

Sobre a Replicor

Replicor é uma empresa biofarmacêutica de capital privado com os dados mais avançados no desenvolvimento da cura para HBV e HDV. A empresa dedica-se a acelerar o desenvolvimento de um tratamento eficaz para pacientes com infecções por HBV e HBV/HDV. www.replicor.com

O texto no idioma original deste anúncio é a versão oficial autorizada. As traduções são fornecidas apenas como uma facilidade e devem se referir ao texto no idioma original, que é a única versão do texto que tem efeito legal.

More Stories By Business Wire

Copyright © 2009 Business Wire. All rights reserved. Republication or redistribution of Business Wire content is expressly prohibited without the prior written consent of Business Wire. Business Wire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Latest Stories
"We've been engaging with a lot of customers including Panasonic, we've been involved with Cisco and now we're working with the U.S. government - the Department of Homeland Security," explained Peter Jung, Chief Product Officer at Pulzze Systems, in this SYS-CON.tv interview at @ThingsExpo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"We're here to tell the world about our cloud-scale infrastructure that we have at Juniper combined with the world-class security that we put into the cloud," explained Lisa Guess, VP of Systems Engineering at Juniper Networks, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
There is a huge demand for responsive, real-time mobile and web experiences, but current architectural patterns do not easily accommodate applications that respond to events in real time. Common solutions using message queues or HTTP long-polling quickly lead to resiliency, scalability and development velocity challenges. In his session at 21st Cloud Expo, Ryland Degnan, a Senior Software Engineer on the Netflix Edge Platform team, will discuss how by leveraging a reactive stream-based protocol,...
"Outscale was founded in 2010, is based in France, is a strategic partner to Dassault Systémes and has done quite a bit of work with divisions of Dassault," explained Jackie Funk, Digital Marketing exec at Outscale, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"With Digital Experience Monitoring what used to be a simple visit to a web page has exploded into app on phones, data from social media feeds, competitive benchmarking - these are all components that are only available because of some type of digital asset," explained Leo Vasiliou, Director of Web Performance Engineering at Catchpoint Systems, in this SYS-CON.tv interview at DevOps Summit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"I think DevOps is now a rambunctious teenager – it’s starting to get a mind of its own, wanting to get its own things but it still needs some adult supervision," explained Thomas Hooker, VP of marketing at CollabNet, in this SYS-CON.tv interview at DevOps Summit at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
Your homes and cars can be automated and self-serviced. Why can't your storage? From simply asking questions to analyze and troubleshoot your infrastructure, to provisioning storage with snapshots, recovery and replication, your wildest sci-fi dream has come true. In his session at @DevOpsSummit at 20th Cloud Expo, Dan Florea, Director of Product Management at Tintri, provided a ChatOps demo where you can talk to your storage and manage it from anywhere, through Slack and similar services with...
"We want to show that our solution is far less expensive with a much better total cost of ownership so we announced several key features. One is called geo-distributed erasure coding, another is support for KVM and we introduced a new capability called Multi-Part," explained Tim Desai, Senior Product Marketing Manager at Hitachi Data Systems, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"I'm here to leverage my secret sauce, which is using outsourced development and the company that I utilize is delaPlex Software and they've basically allowed me to win Fortune 500 companies," noted Justin Witz, CTO of FRA and PlanTools, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"We provide IoT solutions. We provide the most compatible solutions for many applications. Our solutions are industry agnostic and also protocol agnostic," explained Richard Han, Head of Sales and Marketing and Engineering at Systena America, in this SYS-CON.tv interview at @ThingsExpo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"As we've gone out into the public cloud we've seen that over time we may have lost a few things - we've lost control, we've given up cost to a certain extent, and then security, flexibility," explained Steve Conner, VP of Sales at Cloudistics,in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
"We are an IT services solution provider and we sell software to support those solutions. Our focus and key areas are around security, enterprise monitoring, and continuous delivery optimization," noted John Balsavage, President of A&I Solutions, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.
SYS-CON Events announced today that Calligo, an innovative cloud service provider offering mid-sized companies the highest levels of data privacy and security, has been named "Bronze Sponsor" of SYS-CON's 21st International Cloud Expo ®, which will take place on Oct 31 - Nov 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA. Calligo offers unparalleled application performance guarantees, commercial flexibility and a personalised support service from its globally located cloud plat...
As enterprise cloud becomes the norm, businesses and government programs must address compounded regulatory compliance related to data privacy and information protection. The most recent, Controlled Unclassified Information and the EU’s GDPR have board level implications and companies still struggle with demonstrating due diligence. Developers and DevOps leaders, as part of the pre-planning process and the associated supply chain, could benefit from updating their code libraries and design by in...
"Peak 10 is a hybrid infrastructure provider across the nation. We are in the thick of things when it comes to hybrid IT," explained Michael Fuhrman, Chief Technology Officer at Peak 10, in this SYS-CON.tv interview at 20th Cloud Expo, held June 6-8, 2017, at the Javits Center in New York City, NY.